Results from PEPPI prediction of p53-mediated cellular senescence protein-protein interactions.
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posted on 2025-05-02, 17:36 authored by Romani Osbourne, Kelly M. ThayerResults from PEPPI prediction of p53-mediated cellular senescence protein-protein interactions.
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relative evolutionary scoringidentify phylogenetically significantgain crucial insightscorrelating genotypic differencesamino acid changestad ), prolinetumor suppressive proteinrplars &# 8217length p53 alignmentsprd ), regulatoryreg ),regulatory pathwaysprotein complexesbased proteinxlink ">species genotyperplars mayrepair mechanismphylogenetic relationshipsp53 stabilitymediated regulationmechanistic diversitylargely unexploredinteraction interfacesexperimental validationcorrelated residuesconcentrated primarilybinding regionsbinding domainbased workflowassociated residuesaligned sequences
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