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Performance of computational alanine scanning ΔΔG prediction for antibody-antigen interfaces.

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posted on 2021-09-07, 17:49 authored by Rui Yin, Johnathan D. Guest, Ghazaleh Taherzadeh, Ragul Gowthaman, Ipsa Mittra, Jane Quackenbush, Brian G. Pierce

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    PLOS Computational Biology

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    viral variant mutationsless effectively targetedprotective antibody responsesdetailed molecular understanding2 pandemic highlightscurrent monoclonal antibodiesdisrupt antibody recognitionantibody recognitiondetailed structure2 variants2 ),neutralizing antibodiesclassified antibodiesantibodies predictedxlink ">revealing setsrbd structuresrbd ),inform therapeuticincluding alphahigh resolutionepitope residuesconservation featurescomprehensive mapbased referencealso identified

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