Overall structures of nsp14-N7-MTase-compound complexes.
journal contribution
posted on 2023-07-31, 17:33 authored by Jithesh Kottur, Kris M. White, M. Luis Rodriguez, Olga Rechkoblit, Richard Quintana-Feliciano, Ahana Nayar, Adolfo García-Sastre, Aneel K. Aggarwal(A) Overall structure of SARS-CoV-2 nsp14-N7-MTaseSGC0946 complex fused with TELSAM. The nsp14 N7-MTase domain and TELSAM are colored in cyan and yellow, respectively. (B) Overall structure of SARS-CoV-2 nsp14-N7-MTaseSGC8158 complex fused with TELSAM. (C) Cα trace superposition of nsp14 N7-MTaseSAM (7TW7), nsp14 N7-MTaseSGC0946 and nsp14 N7-MTaseSGC8158.
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positing novel features5 &# 8217rna binding sitesprmt7 inhibitors provide2 &# 8217mtase core identify2 nsp14 n7rna n72 n72 nsp14substrate inhibitorsmtase core2 mrnansp14 usesnsp14 proteinxlink ">viral replicationviral mtasetaken togetherreaction byproductnew avenuenew antiviralsmethyl donorincreased potencyidentifying twodeveloping analogscentral rolecell permeabilityadenosyl methionineadenosyl homocysteineaccompanying biophysical
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