Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV
Replicative capacity and associated conservation scores for HIV adaptations observed in this study.
Presence of the T242N adaptation in the HLA-B*57/58-restricted Gag T cell epitope TW10.
Subject information and clinical data of mother/child pairs.
HIV-infected children responded to a broad array of Gag peptides but had a limited response to optimal CD8
T cell epitopes, including immunodominant T cell epitopes.
Adaptation scores are correlated with clinical measures of disease outcome in the mother, but not the child.
HIV adaptations occur in the child following transmission.
Adaptation dynamics following transmission affected by bottleneck event, immune selection pressure, replicative cost and drift.
Autologous virus is adapted in both mother and child.
Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV - Fig 2