ppat.1006428.g007.tif (1.9 MB)
Vibrio cholerae augments virulence by modulation of host intestinal methionine sulfoxide reductase.
figure
posted on 2017-06-06, 17:37 authored by Audrey S. Vanhove, Saiyu Hang, Vidhya Vijayakumar, Adam CN Wong, John M. Asara, Paula I. Watnick(A) Wild-type V. cholerae (WT) catabolizes dietary methionine sulfoxide (MetO) in the intestinal lumen, leaving host enterocyte methionine sulfoxide reductase (MsrA) free to repair proteins that have been inactivated by methionine oxidation. (B) In a V. cholerae ΔgcvT mutant infection, dietary MetO is not consumed by V. cholerae but rather taken up by host enterocytes. Dietary MetO competitively inhibits reduction of protein-associated MetO by MsrA within enterocytes.
