iDVGs associate with high expression of antiviral genes in respiratory secretions from patients infected with RSV.
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posted on 2015-09-03, 02:45 authored by Yan Sun, Deepika Jain, Cynthia J. Koziol-White, Emmanuelle Genoyer, Micah Gilbert, Karla Tapia, Reynold A. Panettieri Jr., Richard L. Hodinka, Carolina B. López(A) Representative PCR results for gRSV and DVGs in human nasopharyngeal control samples infected with adenovirus (A1-A5) and samples infected with RSV (R1-R4). (B) Gene expression determined by RT-qPCR shown as copy number relative to house keeping genes (*p<0.05, **p<0.01, by two-tailed Mann Whitney test). (C) Samples were scored based on the intensity of the DVG amplicons (1–4, absent to highest intensity) and correlated with the level of expression of antiviral genes. (r = correlation coefficient, p<0.0001 for slope deviation from 0).
