Whole-brain three-path mediation analysis results.

(A) Whole-brain three-path mediation analysis with the NAc (MNI: −14, 8, −8), which is from the GLM results shown in Figure 4A, as the first mediator. VMPFC (MNI: 2, 52, −2) was the only significant second brain mediator from the whole-brain search (p<0.05, FWER corrected based on cluster extent, with a primary threshold of p<0.001). (B) Whole-brain three-path mediation analysis with vmPFC (MNI: 2, 52, −2), which is from the results shown in Figure 6A. Right NAc (MNI: 8, 8, −6) was the only significant first brain mediator from the whole-brain search. For more details of path coefficients, see Table S5. ^***p<0.001, two-tailed.