The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
A simple mathematical model recapitulates signaling dynamics and predicts cell fate patterning.
Continuous WNT and NODAL signaling synergize to achieve maximal mesodermal differentiation.
Duration of BMP signaling controls extra-embryonic differentiation at colony edge.
WNT enhances and NODAL inhibits BMP signaling at colony edge.
NODAL signaling moves inward independently of BMP and WNT.
Regulation of WNT signaling activity by BMP, WNT, and NODAL.
Inward movement of signaling activities is not due to cell movement.