TF networks within the WGCNA modules over the course of influenza illness.

(A-D) Groups, or modules, of co-regulated DEGs were identified by WGCNA. Representative Gene Ontology (GO) categories for each module were identified by functional enrichment analysis and shown in Table 6. Module expression patterns across different time points were represented by violin plots of log₂ fold-change in gene expression relative to baseline. (E-H) Pscan was used to scan the promoter regions of all genes in each module and identify the over-represented transcription factor binding sites (TFBS). The predicted transcription factors, which marked in red and their target genes (z-score > 2) were connected by edges in the networks.