Structural Conservation and Protein-Kinase Fold in ROP18 and Related Proteins

The side chains of residues strictly conserved among PDB1PHK and various ROP2s (ROP17, 18, 2L3, and 2L4) are shown in black and wire-frame on the backbone of PDB1PHK. The hydrophobic segment (corresponding here to residues 443 to 463 in ROP18) is in black colour and appears buried into the all-alpha domain. The ATP molecule is shown in black and thick wire-frame in order to localise the active site in which conservation corresponds mainly to catalytic residues. Residue numbering refers to the ROP18 sequence.