Signature to predict risk in patients with and without adjuvant therapy.

(A) Signature to predict risk in patients with adjuvant therapy. The signature was developed with patients receiving adjuvant therapy separated by their median survival into two groups, a high risk group with shorter survival and a low risk group with longer survival. A classifier trained with the signature using leave-one-out cross-validation shows a significant difference between the predicted low and high risk group (, logrank test). (B) Signature to predict risk in patients without adjuvant therapy. The signature was developed with patients not receiving adjuvant therapy separated by their median survival into two groups, a high risk group with shorter survival and a low risk group with longer survival. A classifier trained with the signature using leave-one-out cross-validation shows a significant difference between the predicted low and high risk group (, logrank test).