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Setdb2 expression by Mϕ influences T cell proliferation in IAV-infected lungs.
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posted on 2016-01-05, 14:55 authored by Danielle N. Kroetz, Ronald M. Allen, Matthew A. Schaller, Cleyton Cavallaro, Toshihiro Ito, Steven L. Kunkel(A, B) Control and Setdb2ffLyz2cre+ mice infected with 1 x 104 PFU of IAV and euthanized on days 6, 8, and 10 post-infection. (A) The number of CD4+ and CD8+ T cells in IAV-infected lungs. (B) To measure proliferation, mice were injected with the thymidine analogue EdU one day prior to euthanization. The number of proliferating (EdU+) CD4+ and CD8+ T cells was calculated over the indicated time course. Values represent mean ± SEM (n = 5–20 mice) from 2–4 independent experiments. *p<0.05; **p<0.01; ***p<0.001 (relative to control lungs).
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ccrMx 1 transcriptIAV infectionSETDB 2Macrophages Suppresses Innatefactor 7 bindKnockout miceencounter IAV virionsstatM Φ3kifnalveolar M ϕIAV infection resultsInterferon Induced Epigenetic RegulationSetdb 2LacZ reporter miceSetdb 2 expressionlysine methyltransferase Setdb 2Acute Respiratory Viral Infection InfluenzacclSilencing Setdb 2 activityilEnhanced host protection
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