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Schematic model of complex I and its pumping modules.

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posted on 2011-08-23, 00:59 authored by Stefan Dröse, Stephanie Krack, Lucie Sokolova, Klaus Zwicker, Hans-Dieter Barth, Nina Morgner, Heinrich Heide, Mirco Steger, Esther Nübel, Volker Zickermann, Stefan Kerscher, Bernhard Brutschy, Michael Radermacher, Ulrich Brandt

Our data are consistent with the dissection of complex I into four functional modules [6] and allow the assignment of subunits and proton pumps to the proximal (PP, green) and distal (PD, cyan) domains of the membrane arm. The FMN containing N-module (light yellow), the Q-module harbouring the ubiquinone binding site (dark yellow), the chain of seven iron-sulfur clusters (orange spheres), and the extended transmission element (magenta) are indicated.

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