Figure_7.tif (2.04 MB)
Model of SREC-I role in nasal colonization.
figure
posted on 2014-05-01, 03:36 authored by Stefanie Baur, Maren Rautenberg, Manuela Faulstich, Timo Grau, Yannik Severin, Clemens Unger, Wolfgang H. Hoffmann, Thomas Rudel, Ingo B. Autenrieth, Christopher WeidenmaierSREC-I can be detected on growing nasal epithelial cells in the inner nasal cavity. S. aureus WTA binds to SREC-I which mediates S. aureus adhesion to cells from the inner nasal cavity. This WTA/SREC-I interaction has a considerable impact on nasal colonization. Therefore, we postulate a reservoir of S. aureus cells in the inner nasal cavity as a source for continuous colonization, which is at least partially maintained by WTA dependent adhesion to epithelial cells.
