ppat.1008473.s003.tif (268.92 kB)
ZBP1-expressing HT-29s with T+S+V retain the ability to undergo necroptosis.
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posted on 2020-07-10, 17:39 authored by Megan Steain, Max O. D. G. Baker, Chi L. L. Pham, Nirukshan Shanmugam, Yann Gambin, Emma Sierecki, Brian P. McSharry, Selmir Avdic, Barry Slobedman, Margaret Sunde, Allison AbendrothZBP1 expressing HT-29s were treated with DMSO (No treatment, NT) or with TNF (T; 30 ng/ml), BV-6 (S; 1 μM), z-VAD-fmk (V; 25 μM) for 18 h then cell viability measured using the Promega Cell Titre Glo2 assay.
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Varicella zoster virushost cell deathZBP 1-driven apoptosisVZV infectionVZV capsid triplex proteinamyloid complexesTNF-induced necroptosisdecoy amyloid assembliesZBP 1 pathwaysequestering ZBP 1RIP Homotypic Interaction Motifhost cell death inhibitorVZV ORF 20 RHIMVaricella zoster virus encodesRIPKcell death HerpesvirusesORF 20 RHIMORF 20 RHIM formsZBP 1-expressing HT -29 cells
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