This figure shows the cumulative frequency distribution (CFD) for a sample consisting of the 401 differentiation gene ER parameter sets generated by ABC which best fit the synthetic data shown in Fig 2(a), i.e. SSA simulated data for the default stochastic ER differentiation system (see Table A in S1 File).

Out of these 401 parameter sets, 94 satisfy the constraints associated with the differentiation epiphenotype. Amongst these, 10 are found to show plastic behaviour. The remaining 307 parameter sets generate bistability at e_HDM = e_HDAC = 1. Colour code: blue and red lines correpond to the CFD of the plastic and refractory differentiation epiphenotypes, respectively. Green lines correspond to the CFD of the parameters that generate bistability at e_HDM = e_HDAC = 1. Cyan lines correspond to the CFD of a uniform distribution, which we add for reference.