ppat.1011811.g008.tif (1.57 MB)
The conservative and variable antigen sites of FMDV serotype A recognized by bovine neutralization antibodies.
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posted on 2023-11-20, 18:46 authored by Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin LiuFour conservative antigen sites were indicated with pink and respectively determined by bnAb W125 (site 2), W153 (site 3), W2 (site 4) and W145 (site 5). The variable antigen sites involving the position 68 and 175 on VP3 that were recognized by A/AF72-specific and A/GDMM/2013-specific antibodies were marked with oranges.
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spectrum molecular vaccinemouth disease viruskey residues locatedbovine sequentially vaccinatedvariable within serotypes19 ), respectivelyvariable antigenic sitesvp3 scattering aroundvp3 175 positionrevealed antigenic variationrelatively stable vp2div >< psea97 lineage ),variable antigen structurestwo bnabs w2conserved antigen structuresvariable vp3sea97 lineagebait antigenw2 concentratedcontact sitesrespectively useddetermined respectivelya22 lineageem structuresvp3 68well resolvedviral particleresistant mutantsg2 genotypeg1 genotypefold axisepitopes recognizeddriven variationsdifferent strainsdesign broadbnab w15339 strain
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