ppat.1008473.g003.tif (130.94 kB)
The VZV ORF20 RHIM is not involved in TNF-induced necroptosis.
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posted on 2020-07-10, 17:39 authored by Megan Steain, Max O. D. G. Baker, Chi L. L. Pham, Nirukshan Shanmugam, Yann Gambin, Emma Sierecki, Brian P. McSharry, Selmir Avdic, Barry Slobedman, Margaret Sunde, Allison Abendroth(A) Viability of mock, VZV and VZV RHIM mutated (VZV-RHIMmut) virus infected HT-29s (72 h post-infection) following treatments with TNF (T; 30 ng/ml), BV-6 (S; 1 μM), z-VAD-fmk (V; 25 μM) and necrostatin-1 (Nec1; 30 μM) alone or in combination as indicated. Data was normalised to DMSO only control. Error bars show standard error of the mean, from 4 independent replicates and statistical significance was determined using a two-way ANOVA.
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Varicella zoster virushost cell deathZBP 1-driven apoptosisVZV infectionVZV capsid triplex proteinamyloid complexesTNF-induced necroptosisdecoy amyloid assembliesZBP 1 pathwaysequestering ZBP 1RIP Homotypic Interaction Motifhost cell death inhibitorVZV ORF 20 RHIMVaricella zoster virus encodesRIPKcell death HerpesvirusesORF 20 RHIMORF 20 RHIM formsZBP 1-expressing HT -29 cells
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