pcbi.1007653.g001.tif (619.13 kB)
Simulation scheme.
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posted on 2020-03-27, 17:34 authored by Shani Inbar, Pnina Cohen, Tal Yahav, Eyal PrivmanAllele frequencies of 10,000 SNPs are sampled from an empirical distribution. Genotypes were randomized for the mother and five fathers of each colony, and then for 30 of their daughter workers. The corresponding pool allele frequencies were sampled according to the empirical correlation between pools and individuals. Colony level phenotypes were generated based on the individual genotypes at a single phenotype-affecting SNP and at varying environmental noise levels. The success rate for detecting the causal SNP was determined for 100 simulated datasets.
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GWASCataglyphis niger antssampleQTL detection powerpopulation genomic approachesrepresentation genomic sequencingwhole-genomeallele frequency estimationDNApool-seqindividualalternative approachesmapping colony-level traits Social insect colonies exhibit colony-level phenotypescolony-level traitsaccuracysequencing un-normalized pools
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