Model schematic.
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posted on 2022-09-20, 17:43 authored by Mitchel J. Colebank, Naomi C. CheslerThe computational model here consists of a lower order simulator of sarcomere dynamics within the left atrium (LA), left ventricle (LV), right atrium (RA), right ventricle (RV), and septum (S). The LV, RV, and S are simulated using the TriSeg model [8], and account for biventricular interaction. Lastly, a circuit model is used to describe the systemic arteries (SA) and veins (SV), as well as the pulmonary arteries (PA) and veins (PV).
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single point systolicpractically identifiable priorpractical identifiability issueslarge forecast uncertaintybased confidence intervalspulmonary vascular diseasenoise corrupted datamodel forecast uncertaintypractical identifiability analysislocal sensitivity analysisstudy ventricular functionvolume data revealsprovided key insightdiastolic lv datadependent lv pressureadditional left ventricularrv pressure suffersvolume dataright ventricularquantitative datapulmonary hypertensionmodel calibrationhemodynamic functiondata collectionvivo used modelingsubstantially reducedsilico right ventricleresults showparameters usingoutput spacemorris screeningknowledge gapexperimental designsbiventricular mechanics
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