ppat.1006614.g001.tif (3.04 MB)
HIV Env trimer N-glycans and the CD4bs.
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posted on 2017-09-13, 17:48 authored by Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B. Karlsson Hedestam, Andrew B. Ward, Richard T. WyattStructure of soluble BG505 SOSIP.664 HIV trimer (PDB accession number 5FYL) with gp120 in gray, gp41 in brown and the CD4bs shown as a magenta surface. N-glycans are shown in shades of blue. (a) The Group A N-glycans proximal to the CD4bs are shown in dark blue as indicated in bold and the N332 N-glycan is shown in dark turquoise. (b) The Group B N-glycans proximal to the CD4bs are shown in dark blue and are indicated in bold. N332 N-glycan is shown in dark turquoise. (c) Trimer docking models of VRC01 (purple), b12 (red) and CH103 (yellow) Fabs, each approaching the CD4bs with different angles of access.
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16055 PNGS-deleted trimersHIV Env NFL trimer integrityCD 4 receptor engagementCD 4bsïve B cellswell-ordered clade C 16055CD 4bs bNAbsB cell repertoireresidue N 276rabbit immunogenicity experimentsB cell responsesantibodyglycosylated NFL trimersCD 4 binding siteglycosylated autologous virustier 2 virusesCD 4bs viruses4 PNGS sitesTargeted N-glycan deletionneutralizing determinantHIV envelope glycoproteinsN-glycan-deleted trimer variantsglycan-deleted trimer variantsB cell recognition
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