ppat.1008177.g007.tif (270 kB)
HIV-infected children responded to a broad array of Gag peptides but had a limited response to optimal CD8+ T cell epitopes, including immunodominant T cell epitopes.
figure
posted on 2019-12-10, 18:40 authored by Jennifer Currenti, Abha Chopra, Mina John, Shay Leary, Elizabeth McKinnon, Eric Alves, Mark Pilkinton, Rita Smith, Louise Barnett, Wyatt J. McDonnell, Michaela Lucas, Francine Noel, Simon Mallal, Joseph A. Conrad, Spyros A. Kalams, Silvana Gaudieri(A) There was a significantly higher response in the mother than the child for HLA-A-restricted optimal CD8+ T cell epitopes (N = 13, p = 0.03; Wilcoxon signed-rank test) and a trend for HLA-B-restricted optimal CD8+ T cell epitopes (N = 15, p = 0.08). Data are represented as mean ± SE. (B) There was no difference in IFN-γ responses to a Gag peptide pool in the mother and child (N = 24, p>0.9).
