ppat.1011811.s004.tif (643.19 kB)
Density maps of FMDV-AWH-W125 complex and FMDV-AWH-W2 complex.
figure
posted on 2023-11-20, 18:46 authored by Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin LiuSurface representation of the density maps for a protomer of FMDV-AWH-W125 complex (A) and FMDV-AWH-W2 complex (B). VP1, VP2, VP3 and VP4 of the protomer are blue, green, red and yellow; VH and VL of W125 are purple and orange, respectively; VH and VL of W2 are cyan and magenta, respectively. In the right panel, atomic models shown as sticks are superimposed to indicate the representative regions in wire frames. In the stick models, the residue numbers are indicated. The VP2, VP3, VH and VL residues are labeled with a subscript.
(TIF)
History
Usage metrics
Categories
Keywords
spectrum molecular vaccinemouth disease viruskey residues locatedbovine sequentially vaccinatedvariable within serotypes19 ), respectivelyvariable antigenic sitesvp3 scattering aroundvp3 175 positionrevealed antigenic variationrelatively stable vp2div >< psea97 lineage ),variable antigen structurestwo bnabs w2conserved antigen structuresvariable vp3sea97 lineagebait antigenw2 concentratedcontact sitesrespectively useddetermined respectivelya22 lineageem structuresvp3 68well resolvedviral particleresistant mutantsg2 genotypeg1 genotypefold axisepitopes recognizeddriven variationsdifferent strainsdesign broadbnab w15339 strain
