Broadly neutralizing activity of Tnb04-1 against authentic SARS-CoV-1 and SARS-CoV-2 variants.
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posted on 2024-11-11, 18:41 authored by Haodi Dong, Runhong Zhou, Jing Chen, Jing Wei, Zimeng Wei, Ziqing Yang, Kun Zhu, Yufan Yang, Qianqian Yang, Na Liu, Yuting Chen, Yuhan Wu, Yan Liang, Yige Zeng, Qile Guo, Mingxi Li, Sisi Shan, Han Wang, Mengyue Niu, Isabella Yunfei Zeng, Xuanling Shi, Qi Zhang, Xinquan Wang, Zhiwei Chen, Linqi Zhanga. Actual neutralization curve of Tnb04-1 against diverse clinical isolates of SARS-CoV-1, SARS-CoV-2 WT, Delta, and various Omicron subvariants BA.1, BA.2, BA.5.2, BQ.1.1, XBB, XBB.1.5, and EG.5.1, using focus reduction neutralization test (FRNT). b. The estimated IC50 and IC90 based on neutralization curves in the left panel. The results shown are representatives of two independent experiments and presented as mean ± SEM.
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spike &# 8217conserved hydrophobic pocketcombating respiratory acquisitionauthentic omicron xbb1 holds promisepotent neutralizing capabilitiesdemonstrate exceptionally broadace2 binding site1 sarbecoviruses including sars2 subvariant kp5 subvariant1 emergesxlink ">urgent needsuper broadstudy highlightsresistant corerecently emergedproteinase kpotential threatongoing evolutionintranasal administrationinteraction disruptsimmunized alpacasimmune escapeeffective strategiesdivergent sarscell fusionbinding domain
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