Binding modes of FMDV integrin receptor and antibody.
Binding modes of integrin (avβ6) receptor with scFv antibody W2 (A) and W125 (B). The panel shows a view down onto the capsid surface. VP1, VP2, VP3 and VP4 of the protomer are blue, green, red and yellow, respectively. The integrin and antibodies (W2 and W125) are drawn in cartoon representation; integrin is purple; W2 and W125 are respectively colored with orange and cyan. Black dashed circles show significant clashes between antibody (W2 and W125) and integrin receptor.