A proposed working model for the Dpp dipeptide importer.
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posted on 2025-03-07, 18:27 authored by Panpan Li, Manfeng Zhang, Yihua HuangDiagram of the “alternating-access” mechanism for the DppABCDF dipeptide transporter. In this model, DppA (or dipeptide-bound DppA)-bound DppBCDF structure is unavailable.
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various physiological processesfive distinct subunitsdiv >< pavoiding dipeptides escapingbound dppabcdf adoptspreventing dipeptide backmycobacterium tuberculosis dipeptide transporter dppabcdfstructural studies revealescherichia coli abc transporter dppabcdfbound dppbcdf adoptsamppnp molecule boundcoli complexes bounddipeptide acquisitionstructural observationsstructural characterizationreveals insightsreported heterotrimericperiplasm uponpeptide transportersnegative bacteriaintracellular targetsimportant roleforth bindingfacing conformationem structuresdppbcdf translocatordppbcd translocatorbinding cassetteatpase subunit
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