Regulatory function at the chromosome 10q24 leprosy association.
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posted on 2022-09-19, 17:42 authored by James J. Gilchrist, Kathryn Auckland, Tom Parks, Alexander J. Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A. Rockett, Ousmane B. Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A. Djimdé, Mahamadou A. Thera, Ogobara K. Doumbo, Samba Sow, Sian Floyd, Jörg M. Pönnighaus, David K. Warndorff, Amelia C. Crampin, Paul E. M. Fine, Benjamin P. Fairfax, Adrian V. S. HillEvidence for colocalisation between regulatory determinants of gene expression at 25 genes in cis (within 250kb) to the leprosy association across primary immune cells, skin and peripheral nerve tissue.
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wide association studysup >&# 8722selection pressure drivenrecent positive selectionperipheral nerves causedone population mayinfectious disability globallydespite recent improvementscharacterise regulatory activity81 × 1030 susceptibility lociinflammatory bowel diseaseestablished risk locidisease insights deriveddiv >< pmycobacterium leprae shared genetic architecturelocus shows evidence40 − 0mali genetic architecturedisease controlatopic diseasep leprosy riskslc29a3 lacc1 actr1a using publiclyuncertain whethersignificant burdenpreviously describedonset asthmamodern populationsmhc classindian populationsimportant causedemonstrates pleiotropydata highlightsci 0chronic infectioncandidate mediatoravailable dataafrican populations64 ]).436 controls368 controls327 cases247 cases
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