MaAsLin 2 associations between HMP2 multi-omics features (unstratified RNA pathways) and covariates.
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posted on 2021-11-16, 18:35 authored by Himel Mallick, Ali Rahnavard, Lauren J. McIver, Siyuan Ma, Yancong Zhang, Long H. Nguyen, Timothy L. Tickle, George Weingart, Boyu Ren, Emma H. Schwager, Suvo Chatterjee, Kelsey N. Thompson, Jeremy E. Wilkinson, Ayshwarya Subramanian, Yiren Lu, Levi Waldron, Joseph N. Paulson, Eric A. Franzosa, Hector Corrada Bravo, Curtis HuttenhowerList of statistically significant associations (FDR<0.25) between unstratified RNA pathways and IBD disease phenotype (with non-IBD as reference), IBD dysbiosis state (with non-dysbiotic as reference), age, and antibiotic use using MaAsLin 2’s default multivariable linear mixed effects model with subject and site as random effects (S3 Text). Features are sorted by minimum FDR-adjusted p-values. For each feature, coefficient estimates and test statistics and the associated two-tailed p-values are also reported. Input features and metadata are also provided.
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simulation studies revealmultivariable association discoverymodern epidemiological studiesinflated ), highinflammatory bowel diseaseshuman health outcomesg ., countscontrolling false discoveryassess multivariable associationintegrative human microbiomereproducing established resultsscale observational studiesmicrobiome multivariable associationsmicrobial community measurementsmicrobial community featuresmicrobiome multimicrobial multiestablished methodologyscale evaluationrepeated measurementscompositional measurementsassociate featuresomics associationsomics featuresxlink ">without covariatestypically noisystraightforward identificationrepeated measuresrelative abundancesquantitative propertiesoptimized combinationmultiple covariatesmixed modelsmaaslin 2longitudinal designsintegrated landscapeincluding crossextremely nonenvironmental conditionsdata typesbroad range
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