ppat.1008014.g001.tif (363.59 kB)
Mal and Cav1 gene expression is enriched in brain endothelial cells.
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posted on 2019-11-08, 18:34 authored by Jennifer R. Linden, Claudia Flores, Eric F. Schmidt, Francisco A. Uzal, Adam O. Michel, Marissa Valenzuela, Sebastian Dobrow, Timothy Vartanian(A) Heatmap showing the enrichment of cell type marker genes in the TRAP IPs from oligodendrocytes, endothelial cells, pericytes, astrocytes, L5b pyramidal cells, and inhibitory interneurons compared to whole cortex input. Gray boxes indicate a failure to detect (ND) the gene in the data set. (B, C) Mean ± SEM of the ratio of Mal (B) and Cav1 (C) expression (log2 fold change of RPKMs) in TRAP IP mRNAs compared to whole cortex input mRNAs in each of the CNS cell types from A. Dotted lines indicate 2-fold enrichment (positive value) or depletion (negative value).
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RABMAL Clostridium perfringens epsilon toxinClostridium perfringens epsilon toxinendosomeEEAInternalized caveolae fuselipid raft-dependent vacuolation60 kDA serum albumin155 kDA IgGmultivesicular bodies fuse basallyCNS microvasculaturecaveolae-dependent transcytosisETX causes blood brain barrier70 kDa dextranETX causes BBB permeability376 Da fluorescein saltETX bindingmultivesicular bodiesblood brain barrier permeabilityETX-induced BBB permeabilityexhibit ETX-induced BBB permeability
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