Tim regulates resistance to infection by S. pneumoniae and S. marcescens.

Mutants lacking resistance, or bacterial killing, have shorter survival times and greater bacterial loads than wild-type flies. Tim null mutants lack resistance to (A) S. pneumoniae and (B) S. marcescens. Tim mutants have bacterial loads similar to wild-type flies when infected with (C) B. cepacia and (D) S. typhimurium. p-values were obtained by two-tailed, unpaired t-test; all experiments were performed with day-time injections.