Figure_3.tif (477.45 kB)
Temporal transcriptional induction of SrbA and SrbB in response to Hypoxia Reveals SrbB transcript levels are induced prior to SrbA.
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posted on 2014-11-06, 03:46 authored by Dawoon Chung, Bridget M. Barker, Charles C. Carey, Brittney Merriman, Ernst R. Werner, Beatrix E. Lechner, Sourabh Dhingra, Chao Cheng, Wenjie Xu, Sara J. Blosser, Kengo Morohashi, Aurélien Mazurie, Thomas K. Mitchell, Hubertus Haas, Aaron P. Mitchell, Robert A. CramerAspergillus fumigatus wild type was cultured in normoxia at 37°C for 18 hours and shifted to hypoxia for additional incubation for 5, 15, and 30 minutes. Data are presented as the mean and standard error of three biological replicates. Compared to normoxia (Hyp 0′), srbB expression was significantly induced in hypoxia 15 min, which was earlier than the initial srbA induction. The data were analyzed by two-way ANOVA followed by Bonferroni posttests.
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hypoxiaipainfection site adaptationSrbA target geneheme biosynthesishypoxic conditions accountsinfection site pathobiologyAspergillus fumigatus SREBP SrbAelement binding proteinFungal Hypoxia ResponsednaVivo Transcriptome AnalysesSrbBvirulenceAspergillus fumigatus sterolantifungal drug resistanceSrbA transcriptional regulation
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