Stimulation of iNKT Cells with α-GalCer during an Established Infection Exacerbates <i>L. donovani</i> Growth in the Liver.

<p>C57BL/6 mice were infected with <i>L. donovani</i> and treated with either vehicle control (open bars) or 2 µg α-GalCer (closed bars) i.p., or injected i.v. with 5×10<sup>5</sup> vehicle-pulsed BMDC (open bars) or α-GalCer-pulsed BMDC (closed bars) on day 14 p.i.. Parasite burdens were determined in the liver at day 14 p.i. in untreated mice (grey bars; base-line parasite burden) and 1 wk later in treated groups, as indicated (A). Data represent the mean±SEM of parasite burdens (LDU) from four mice per group. Serum TNF (B) and IFNγ (C) levels at indicated time points are also shown. Statistical differences of <i>p</i><0.05 (*) for vehicle versus α-GalCer treatment are indicated.</p>

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