Figure_4.tif (121.27 kB)
Stimulation of iNKT Cells with α-GalCer during an Established Infection Exacerbates L. donovani Growth in the Liver.
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posted on 2008-02-29, 01:56 authored by Amanda C. Stanley, Yonghong Zhou, Fiona H. Amante, Louise M. Randall, Ashraful Haque, Daniel G. Pellicci, Geoff R. Hill, Mark J. Smyth, Dale I. Godfrey, Christian R. EngwerdaC57BL/6 mice were infected with L. donovani and treated with either vehicle control (open bars) or 2 µg α-GalCer (closed bars) i.p., or injected i.v. with 5×105 vehicle-pulsed BMDC (open bars) or α-GalCer-pulsed BMDC (closed bars) on day 14 p.i.. Parasite burdens were determined in the liver at day 14 p.i. in untreated mice (grey bars; base-line parasite burden) and 1 wk later in treated groups, as indicated (A). Data represent the mean±SEM of parasite burdens (LDU) from four mice per group. Serum TNF (B) and IFNγ (C) levels at indicated time points are also shown. Statistical differences of p<0.05 (*) for vehicle versus α-GalCer treatment are indicated.