Intracellular Ca<sup>2+</sup> and Na<sup>+</sup> accumulation in five virtual cell variants during increasingly fast pacing.

<p>(A&B) Ca<sup>2+</sup> accumulation and corresponding activation of the reverse mode of NCX in four cell model variants (normalized to nSR). (C&D) Na<sup>+</sup> accumulation and corresponding activation of the forward mode of NCX (normalized to nSR).</p>

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