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Effects of Bw4Ile80 and KIR3DS1 Gene Carriage on HIV Disease Outcome

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posted on 2007-04-20, 00:22 authored by Jason D Barbour, Uma Sriram, Stacy J Caillier, Jay A Levy, Frederick M Hecht, Jorge R Oksenberg

(A) Those with KIR3DS1 (dashed line) versus those without KIR3DS1. The dashed red line represents a moving average of HIV-1 RNA levels over time among those carrying at least one KIR3DS1 allele. The solid red line represents those that do not carry the KIR3DS1 allele. The dashed blue line represents a moving average of CD4+ T cell counts over time among those carrying at least one KIR3DS1 allele. The solid blue line represents those that do not carry the KIR3DS1 allele.

(B) Those with Bw4Ile80 (dashed line) versus those without Bw4Ile80. The dashed red line represents a moving average of HIV-1 RNA levels over time among those carrying at least one Bw4Ile80 allele. The solid red line represents those that do not carry the Bw4Ile80 allele. The dashed blue line represents a moving average of CD4+ T cell counts over time among those carrying at least one Bw4Ile80 allele. The solid blue line represents those that do not carry the Bw4Ile80 allele.

(C) Those with both the Bw4Ile80 and KIR3DS1 alleles (dashed line) versus those without both alleles. The dashed red line represents a moving average of HIV-1 RNA levels over time among those carrying both the Bw4Ile80 and KIR3DS1 alleles. The solid red line represents those that do not carry both the Bw4Ile80 and KIR3DS1 alleles. The dashed blue line represents a moving average of CD4+ T cell counts over time among those carrying at both the Bw4Ile80 and KIR3DS1 alleles. The solid blue line represents those that do not carry both the Bw4Ile80 and KIR3DS1 alleles.