Disease-specific networks of drug-food interactions on proteins affecting drug pharmacodynamics.
Node shape denotes drug target (circle), drug (triangle) and food (diamond). Edge color highlights the food compound (phytochemical) that shows the highest binding activity to the effect target. Edge width denotes the biological activity (Ki, IC50) and ranges between 1nM to 1000 nM. For visualization purposes, only 3 drugs and 3 foods with the highest biological activities are shown for each drug target, while the complete data are provided as supplementary material (S3 Table).