Fig 4.tif (1.57 MB)
Bromodomain inhibition is reversible and “memory” of the active ES is retained.
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posted on 2015-12-08, 12:47 authored by Danae Schulz, Monica R. Mugnier, Eda-Margaret Paulsen, Hee-Sook Kim, Chun-wa W. Chung, David F. Tough, Inmaculada Rioja, Rab K. Prinjha, F. Nina Papavasiliou, Erik W. Debler(A) Flow cytometry measuring the amount of anti-VSG antibody bound to the cell surface as well as surface levels of EP1 following treatment with I-BET151 for the indicated number of days. (B) Flow cytometry measuring surface levels of VSG and EP1 following a 5-d treatment with I-BET151, washout, and recovery for 3 d (top two panels) or 4 d (bottom two panels). Numerical data for Fig 4 is in S4 Data.
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Bloodstream Form Stage Identitynovel binding modeimmunogenic surface VSGAfrican Trypanosome Trypanosoma bruceibromodomain inhibitionhost antibody responses1.25Å resolution crystal structureBF cell fatebromodomain proteinstrypanosome bromodomain proteinsbloodstream stage identityimmunogenic Variant Surface Glycoprotein
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