Workflow of the methodology employed to compare the flanking regions of ERVs versus control regions.

The comparison between the flanking regions of two different ERV types utilizes an analogous pipeline. (A) Generation of windows and data. (B) Schematic of the nine comparisons implemented in our study. (C) Schematic of the statistical analysis, including Functional Data Analysis techniques. FLR: Functional Logistic Regression, ITP: interval testing procedure, IDL: invariant differential landscape, LDL: localized differential landscape.