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Summary schematic: Identified regions in E6AP important in mediating E6 binding and cellular protein degradation.

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posted on 2020-01-23, 18:37 authored by Camille M. Drews, Nicole Brimer, Scott B. Vande Pol

The herein identified and described regions within E6AP are indicated as being important in mediating E6 binding and/or in E6-mediated degradation of cellular proteins.

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    PLOS Pathogens

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    Keywords

    autism spectrum disordersHECT domain E 3 ubiquitin ligase E 6APE 6-E interaction typesType II interactionscarboxy-terminal HECT ubiquitin ligase domainUBE 3AE 6AP amino-terminalE 6APE 6-EregionNHERFneurodevelopment disorder Angelman Syndromeubiquitin ligase activitycarboxy-terminal HECT domainpapillomavirus E 6 proteinsE 6 associationType II interactionLXXLL peptide motifHPV E 6 proteinsE 6 proteinsE 6

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