Regulation of browning and BAT activation by p38 pathway.

Graphical abstract summarising the role of p38 isoforms in adipose tissue. In eWAT, p38α activates browning through the phosphorylation of Creb and ATF2 increasing UCP1 expression. In iWAT and BAT, p38α activation inhibits p38γ and p38δ and in consequence reduces browning and BAT activation, respectively, by down-regulation of UCP1. ATF2, activating transcription factor 2; BAT, brown adipose tissue; Creb, cAMP response element-binding; eWAT, epididymal fat; iWAT, inguinal fat; UCP1, uncoupling protein 1.