Illustration of WAP scores.

A: Gene products are scored for their association xi (number of interactions) to the top i DEGs, where i varies from 1 to the total number n of genes. Values of xi are compared via edge-count probabilities Pi, and a gene product is scored with its best corrected attachment p-value: c mini Pi. B: The profile of ranked c min P values is compared to profiles estimated after randomly assigning disease and control labels to samples (104 permutations). This yields an estimated Proportion of False Positive (PFP) of WAPs at each rank j.