ppat.1008177.g003.tif (301.77 kB)
Autologous virus is adapted in both mother and child.
figure
posted on 2019-12-10, 18:39 authored by Jennifer Currenti, Abha Chopra, Mina John, Shay Leary, Elizabeth McKinnon, Eric Alves, Mark Pilkinton, Rita Smith, Louise Barnett, Wyatt J. McDonnell, Michaela Lucas, Francine Noel, Simon Mallal, Joseph A. Conrad, Spyros A. Kalams, Silvana GaudieriThe proportion of known HIV adaptations observed in the autologous virus of mother/child pairs. (A) Adaptations were separated into three groups: 1) shared maternal HLA alleles present in both mother and child; 2) paternal HLA alleles only present in the child; and 3) mother-only HLA alleles present only in the mother. (B) Adaptations based on location within HIV proteins Gag, Pol, and Nef. (C) Adaptations sorted by HLA locus. All analyses were performed using mixed-effects logistic regression incorporating HLA inheritance, HIV protein, and HLA locus. Data are represented as mean ± SE. N = 23, p<0.0001 (****), p<0.001 (***), p<0.01 (**), p<0.05 (*).
