ࡱ >
\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table_2 l ^ Protein (units) Gene
SNP
MAF Distance (bp) Mean trait values GC P
Perm P 11 12 22 TNFa (pg/ml)
ABO rs505922 0.34 intron 2 . 6 8 ( 2 . 5 3 2 . 8 5 ) 1 . 6 6 ( 1 . 6 1 1 . 7 2 ) 1 . 7 1 ( 1 . 5 9 1 . 8 4 ) 6.7610−40 <0.0001 IL-6sR (ng/ml) IL6R rs4129267 0.37 6 9 . 9 2 ( 6 6 . 9 5 7 2 . 9 9 ) 1 0 0 . 6 5 ( 9 6 . 9 7 1 0 4 . 4 4 ) 1 3 8 . 1 3 ( 1 2 9 . 9 4 1 4 6 . 7 7 ) 1.8210−57 <0.00001 MIPb (pg/ml)
CCL4L2 rs4796217 227353 7 4 . 7 4 ( 6 8 . 8 5 8 1 . 0 3 ) 5 3 . 3 2 ( 4 8 . 6 4 5 8 . 3 4 ) 2 7 . 2 1 ( 2 1 . 4 8 3 3 . 8 3 ) 3.8710−21 IL18 (ug/ml) IL18 rs2250417 0.44 50476 4 0 6 . 7 9 ( 3 9 2 . 6 6 4 2 1 . 4 3 ) 3 6 6 . 5 8 ( 3 5 5 . 3 9 3 7 8 . 1 2 ) 3 3 0 . 7 3 ( 3 1 5 . 8 3 3 4 6 . 3 3 ) 6.7910−13 LPA (mg/dl)
LPA rs7770628 0.49 0.34/0.18 0.46/0.52 0.20/0.30 4.3610−10
GGT1 (u/l) GGT1 rs5751901 0.39 6917 1 7 . 8 6 ( 1 7 . 1 1 1 8 . 6 7 ) 1 9 . 6 ( 1 8 . 8 5 2 0 . 4 1 ) 2 1 . 3 8 ( 1 9 . 8 8 2 3 . 0 7 ) 1.5210−7 0.00076
SHBG (nmol/l) SHBG rs6761* 0.31 115829 1 1 1 . 6 7 ( 1 0 6 . 7 7 1 1 6 . 7 7 ) 1 0 0 . 9 ( 9 6 . 5 5 1 0 5 . 4 3 ) 8 5 . 1 6 ( 7 7 . 6 5 9 3 . 3 1 ) 3.0810−7 CRP (ug/ml)
CRP
rs12093699 0.29 34092 2 . 2 6 ( 2 . 0 7 2 . 4 7 ) 2 . 7 4 ( 2 . 4 8 3 . 0 3 ) 3 . 6 4 ( 2 . 7 7 4 . 7 8 ) 6.3610−6 0.0038
IL1RA (pg/ml) IL1RN rs6761276 43158 1 1 8 . 6 ( 1 1 2 . 4 9 1 2 5 . 0 5 ) 1 4 2 . 1 6 ( 1 3 5 . 7 3 1 4 8 . 8 9 ) 1 4 1 . 2 3 ( 1 2 6 . 7 4 1 5 7 . 3 7 ) 7.2710−6 0.00097
d MbP?_ %
* + &P &F