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Table 1
RBP EM transition regulationH Description of RBPs role in breast cancer and relevant references ZFP36 Activator In vivo and in vitro, NNT-AS1 knockout can inhibit the progression and metastasis of breast cancer by interacting with ZFP36 [36]. LARP4 Inhibitor LARP4 the inhibits migration and invasion of cancer cells [37]. SMAD6M [38] confirmed the importance of BMP signaling in the EM transition process and in vivo invasion. Overexpression of SMAD6 in the estrogen receptor breast cancer cell lines can effectively block BMP signalling. ZCCHC24 ZCCHC24 seems to change the structure of breast cancer cells, increasing the invasiveness of the fatal disease [39]. PIWIL4 PIWIL4 is necessary for the EM transition process [40]. PIWIL4 is a novel estrogen receptor signaling regulator that can be targeted to inhibit the growth and migration of breast cancer [41].
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