ࡱ >
\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table 3 Measure What it indicates Hypothesized change Observed change Percentage of time sleeping Level of sleep disruption* ! p e r c e n t a g e f o r u n p r e d i c t a b l e d i s r u p t i o n s / No change, except for decrease on Day 1 post-op Sleep bout length Level of sleep fragmentation9 ! f o r u n p r e d i c t a b l e d i s r u p t i o n s , ! f o r a n a l g e s i a c o n t r o l s ! f o r f e m a l e m i c e w i t h a n a l g e s i a Activity level Behavioral patterning changes ! p o s t - o p 7 ! i n u n p r e d i c t a b l e d i s r u p t i o n x a n a l g e s i a c o n t r o l g r o u p TINT% P r e s e n c e o f p a i n o r ! g e n e r a l w e l f a r e 4 ! f o r c o n t r o l s a n d u n p r e d i c t a b l e d i s r u p t i o n s p o s t - o p ! f o r a n a l g e s i a c o n t r o l s Sucrose preference" A n h e d o n i a n e g a t i v e e f f e c t i v e s t a t e 7 ! c o n s u m p t i o n f o r u n p r e d i c t a b l e d i s r u p t i o n s a n d p o s t - o p ! c o n s u m p t i o n p o s t - o p Re-epithelialization of wounds Wound healing qualityE ! r e - e p i t h e l i a l i z a t i o n f o r u n p r e d i c t a b l e d i s r u p t i o n s a n d n o a n a l g e s i a
No difference Adrenal cortex:medulla ratio Chronic HPA axis activation% ! r a t i o f o r u n p r e d i c t a b l e d i s r u p t i o n s
d MbP?_ % * + &P &F