Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

Prasse, Antje

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

Posted on 2013-11-20 - 04:10

AM (1x10⁶ cells/well and ml) from healthy donors (HD, n=23; Panel A) and IPF patients (IPF, n=14; Panel B) were cultured in serum-free medium with (coloured bar) or without (white bar) the presence of monomeric collagen type I for 24 hours. Note the 10fold difference in spontaneous M2 cytokine production between AM from IPF patients and HD. Collagen type I exposure of AM significantly enhanced CCL2, CCL18 and IL-1ra production. The effect of collagen type I monomers was more pronounced in AM from IPF. (*, p<0.05; **, p<0.001).

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Stahl, Mirjam; Schupp, Jonas; Jäger, Benedikt; Schmid, Michael; Zissel, Gernot; Müller-Quernheim, Joachim; et al. (2015). Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation. PLOS ONE. Collection. https://doi.org/10.1371/journal.pone.0081382

https://doi.org/10.1371/journal.pone.0081382

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