ppat.1007515.g003.tif (1.6 MB)
vOTU preferences for different di-Ub linkages.
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posted on 2019-01-10, 19:09 authored by John V. Dzimianski, Brianna S. Beldon, Courtney M. Daczkowski, Octavia Y. Goodwin, Florine E. M. Scholte, Éric Bergeron, Scott D. Pegan(A) Activity towards K48, K63, and K11 linked di-Ub FRET-TAMRA substrates. Values shown are the mean ± standard deviation of two independent experiments. (B) Gel cleavage assay of unlabeled di-Ub, visualized by Commassie Blue staining. (C) Summary of currently investigated vOTU di-Ub activity (present study and [32]).
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novel X-ray crystal structuresCrimean-Congo hemorrhagic fever virusRecent genomic characterizationISG 15 fluorogenic substratesHughes orthonairovirus speciesNairoviridae familyvOTU substrate preferencesDUBdeubiquitinase activity Post-translational modificationgene product 15nairovirus genomic diversitytumor domain protease
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