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Almeras, Lionel; Costa, Monique Melo; Amalvict, Rémy; Guilliet, Joseph; Dusfour, Isabelle; David, Jean-Philippe; Corbel, Vincent

doi:10.1371/journal.pone.0303027.s001

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posted on 2024-05-10, 17:35 authored by Lionel Almeras, Monique Melo Costa, Rémy Amalvict, Joseph Guilliet, Isabelle Dusfour, Jean-Philippe David, Vincent Corbel

LSVs following upgrading homemade reference database with MS spectra from legs (A) and thoraxes (B) of the four Ae. aegypti lines. Eighteen specimens per line were tested. Horizontal dashed lines represent the threshold value for reliable identification (LSV>1.8). Red, green, blue and yellow dots correspond to BORA, IR13, IR03 and IRF Ae. aegypti lines, respectively. LSVs, log score values; a.u., arbitrary units.

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tof mass spectrometry simple diagnostic methods rapidly distinguish resistant present study aims div >< p deltamethrin resistant marker breeding history rather bora line compared 11 discriminating peaks insecticide susceptibility profile detect deltamethrin resistance tof ms biotyping unconformity protein profiling track insecticide resistance protein profiles allowed ms profiling may aedes aegypti three inbreeding lines french guiana origin insecticide resistance ms profiling french guiana ms profiles aegypti protein signatures three inbreeds geographical origin ms spectra ms ).ae vector control thorax spectra susceptible phenotypes spreading worldwide site modification routine monitoring reduced penetration pyrethroid insecticides mostly used mosquito control labor intensive ir13 ),identify 10 growing threat first criteria easily detectable dengue vector body parts bias due behavioral changes

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