pcbi.1009293.s024.avi (13.48 MB)
MDCK post-contact-inhibition representative data.
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posted on 2022-04-27, 17:37 authored by Julienne LaChance, Kevin Suh, Jens Clausen, Daniel J. CohenS4 Movie shows MDCK tissue after contact inhibition, imaged at 4x magnification, with overlaid nuclei predictions produced using a neural network (see Methods). This movie is from the dataset as S2 Movie, but it shows the complete progression from an early confluent tissue to a late stage, mature tissue with full contact inhibition and jammed cells.
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physical parameters modifyingmodeling assumptions highlightslearned turning decisionseffectively capture highxlink "> collectiverules change basedtissue type usingkey tissue typescell interaction dynamicsexpansile epithelial tissuesrules &# 8217learned relative influencerelative influencecollective setting&# 8216primary cellneighbor cellmodel tissuedimensional cellsimultaneously expressresults requiremulticellular organismslocation withininterpretable formsimmediate forwardfuture motioncellular trajectoriescellular crowdingbroadly influencedbiophysical contextbiological insightsattention uniqueattention maps
