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posted on 2024-10-31, 17:44 authored by Ananya Datta, Xin Yi Li, Manshul NagpaulqPCR analysis of pro-para-inflammatory cytokines (A) gene expression and (B) protein level was compared with the level of osteopontin gene/protein from 4, 8, 13 and 21 weeks old db/db male mice and WT control mice. Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, [Two-way ANOVA with Tukey’s multiple comparison test]. Note: MMP-9 protein level was not quantifiable at 2 and 4 weeks in WT mice, hence these data are omitted.
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wheat germ agglutininsecreted phosphoprotein knownproinflammatory cytokines associatedkg body weightindicating corneal irregularitiestear production measurementsstandard chow dietocular surface inflammationocular surface diseasesocular surface diseaseenhanced fluorescein stainingcorneal opn levelscorneal fluorescein stainingassessed using elisaxlink "> threeopn -/-) miceopn -/- micetear fluid contributesdetected early postsimilar elevations observedopn also correlateddiabetes remain unexploredblood glucose levels6 became apparentxlink "> osteopontinwt mice treated10 weeks postelevated tear nawga staining showedvehicle ); non2 weeks post16 weeks comparedtype 2 diabeticocular surfacexlink ">weeks posttear fluid10 weekswt micetear sodium2 weeksvehicle aloneperformed usingosteopontin glycoproteinopn precedesfat dietalso included6 weeksearly increaseearly expressionrendered diabeticdiabetic wtdiabetic retinopathydiabetic controlsway anovavarious stagesstatistical analysisspecific rolessignificant reductionsignificance setpreceding changesold c57blmouse retinasmechanistic pathwaysmatrix metalloproteinaseinflammatory processesimmune responsesfuture researchfluorescence intensitydiabetes progressesdiabetes progresseddiabetes onsetded ),clinical signscitrate buffer6 wild40 mg200 mg
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