pcbi.1010822.s003.pdf (52.9 kB)
Download fileEscapability score F from different accessibility scores for past and present SARS-CoV-2 variants of concern.
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posted on 2023-01-24, 18:35 authored by Sören von Bülow, Mateusz Sikora, Florian E. C. Blanc, Roberto Covino, Gerhard HummerEscapability scores are calculated using Eq 1 with a cutoff of 1 nm and are reported for individual spike chains A, B, and C evaluated with the rays, AAS, and SASA scores with glycans (+ glycans) and without glycans (− glycans).
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host immune defensebased immune responsessteric shielding effectnewly emerging sarsexpected mutation activityantibody accessibility scoreaas correlate stronglyvariant spike proteinsomicron variant bahigh calculated escapabilityspike surface mutationssteric accessibilitymutation activityspike proteinsincluding omicronhigh valuesescape antibodyspike proteinxlink ">viral evolutiontime viewstrong predictorsteady emergenceprior infectionprimary targetpinpoint regionsearlier variantse .,available early1 infection
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